BARICADE FOR 5427

Public Outreach

Sodium glucose transporter 2 inhibition maintains kidney antibacterial response by decreasing complement C1q

Sendtner GW, Miranda J, Naumann P, Weiss M, Güls P, Molitor E, Scheidt U, Schmidt A, Ludwig KU, Hilger A, Dobrindt U, Mayrhofer T, Kurts C, Wagenlehner F, Shevshuk O, von Vietinghoff S.

2026 Jan 19

https://pubmed.ncbi.nlm.nih.gov/41565025/
TSP1/TGF-β1 drives arachidonic acid metabolism to orchestrate neutrophil swarming

Widera L, Spangenberg P, Siemes D, Bessler S, Bottek J, Voss H, Novak A, Hueser D, Richter M, Potthoff A, Siebels B, Moritz M, Gocke A, Thiebes S, Tautges S, Chavakis T, Jablonska J, Lämmermann T, Gunzer M, Schlüter H, Hahn J, Grüneboom A, Soehnlein O, Dreisewerd K, Soltwisch J, Shevchuk O, Engel DR

2025 Nov 11

https://www.biorxiv.org/content/10.1101/2025.11.25.688397v1.full.pdf
Low dose glucocorticoids attenuate crescentic glomerulonephritis by inhibiting the local differentiation of pro-inflammatory neutrophils

Yin J, Eichler M, Schaub DP, Asada N, Engesser J, Lisowski C, Paust HJ, Weisheit CK, Li J, Klaus D, Garbi N, von Vietinghoff S, Krebs CF, Panzer U, Kurts C.

2025 Oct 15

https://pubmed.ncbi.nlm.nih.gov/41091917/

Differential perception of virulence factors of uropathogenic Escherichia coli at the level of chromatin dynamics of infected host cells

Krishnendu Mukherjee, Wiebke Aschenbach, Annika Hilger, Judith Saur, Ulrich Dobrindt

2025 Oct 6

https://pubmed.ncbi.nlm.nih.gov/41122162/
LDL receptor promotes urinary tract infection by α-hemolysin-producing Escherichia coli and long-term histopathologic sequelae in the kidney.

Possenriede L, Sendtner GW, Falahat P, Miranda J, Schmidt A, Ludwig KU, von Vietinghoff S.

2025 Sep 23

https://pubmed.ncbi.nlm.nih.gov/40953258/
NaCl and urea modulate CD8+ T cell survival, renal accumulation and response to BK virus.

Falahat P, Goldspink A, Oehler L, Schmitz J, Miranda J, Gammoudi I, Bräsen JH, Klümper N, Babyak O, Kurts C, Haller H, Toma M, von Vietinghoff S.

2025 Aug 26

https://pubmed.ncbi.nlm.nih.gov/40198131/
Residence of mice in metabolic cages reduces experimental kidney inflammation through stress-induced glucocorticoids.

Yin J, Eichler M, Lisowski C, Li J, von Vietinghoff S, Garbi N, Mei Q, Gellner AK, Kurts C.

2025 May 08

https://pubmed.ncbi.nlm.nih.gov/40198131/
Kidney immunology from pathophysiology to clinical translation

Kurts C*, Von Vietinghoff,* Krebs C*, Panzer

2025 Jan 30

https://www.nature.com/articles/s41577-025-01131-y

msiFlow: Automated Workflows for Reproducible and Scalable Multimodal Mass Spectrometry Imaging and Microscopy Data Analysis

Philippa Spangenberg, Sebastian Bessler, Lars Widera, Jenny Bottek, Mathis Richte, Stephanie Thiebes, Devon Siemes, Sascha D. Krauß, Lukasz G. Migas, Siva Swapna Kasarla, Prasad Phapale, Jens Kleesiek, Dagmar Führer, Lars C. Moeller, Heike Heuer, Raf Van de Plas, Matthias Gunzer, Oliver Soehnlein, Jens Soltwisch, Olga Shevchuk, Klaus Dreisewerd, Daniel R. Engel

2025 Jan 27

https://www.nature.com/articles/s41467-024-55306-7
Fecal tryptophan metabolite profiling in newborns in relation to microbiota and antibiotic treatment

Anne-Christine Aust, Veronika Vidova, Katerina Coufalikova et al.

2024 Nov 05

https://pubmed.ncbi.nlm.nih.gov/39500766/
Renal IL-23-dependent type 3 innate lymphoid cells (ILC3) link crystal-induced intrarenal inflammasome activation with kidney fibrosis.

Frasconi TM*, Kurts C*, Dhana E, Kaiser R, Reichelt M, Lukacs-Kornek V, Boor P, Hauser AE, Pascual-Reguant A, Bedoui S, Turner JE, Becker-Gotot J, Ludwig-Portugall I.

2024 Sep 15

https://pubmed.ncbi.nlm.nih.gov/39072698/
Discovery of Antimicrobial Peptides in Urinary Tract Infections

Hannah Voss, Daniel R. Engel, Florian Wagenlehner, Olga Shevchuk

2024 Sep

https://www.eu-focus.europeanurology.com/article/S2405-4569(24)00166-4/fulltext
Influence of Kidney Environment Parameters on Antibiotic Efficacy Against Uropathogenic Escherichia coli

Anne-Christine Aust, Markus Weigel, Jan-Paul Herrmann, Olga Shevchuk, Daniel Robert Engel, Ulrich Dobrindt , Torsten Hain, Florian Wagenlehner

2024 Aug 01

https://pubmed.ncbi.nlm.nih.gov/39089966/
Dual fluorescence reporter mice for Ccl3 transcription, translation, and intercellular communication

Maria Belen Rodrigo, Anna De Min, Selina Kathleen Jorch, Cristina Martin-Higueras, Ann-Kathrin Baumgart, Beata Goldyn, Sara Becker, Natalio Garbi, Niels A Lemmermann, Christian Kurts

2024 Apr 25

https://pubmed.ncbi.nlm.nih.gov/38661718/
Determining individual glomerular proteinuria and periglomerular infiltration in a cleared murine kidney by 3D fast-marching algorithm.

Böhner AMC, Effland A, Jacob AM, Böhner KAM, Abdullah Z, Brähler S, Attenberger UI, Rumpf M, Kurts C.

2024 Mar 06

https://www.kidney-international.org/article/S0085-2538(24)00172-8/fulltext
Cefepime–Taniborbactam in Complicated Urinary Tract Infection

Florian M. Wagenlehner, M.D., Leanne B. Gasink, M.D., Paul C. McGovern, M.D., Greg Moeck, Ph.D., Patrick McLeroth, M.D., MaryBeth Dorr, Ph.D., Aaron Dane, M.Sc., and Tim Henkel, M.D., Ph.D. for the CERTAIN-1 Study Team

2024 Feb 15

https://www.nejm.org/doi/10.1056/NEJMoa2304748
Oral gepotidacin versus nitrofurantoin in patients with uncomplicated urinary tract infection (EAGLE-2 and EAGLE-3): two randomised, controlled, double-blind, double-dummy, phase 3, non-inferiority trials

Prof Florian Wagenlehner, MD, Caroline R Perry, PhD, Prof Thomas M Hooton, MD, Nicole E Scangarella-Oman, MSc, Helen Millns, PhD, Marcy Powell, MD, Emily Jarvis, MSc, Jeremy Dennison, MD, Amanda Sheets, PhD, Deborah Butler, BS, John Breton, MCM, Salim Janmohamed, MD

2024 Feb 08

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02196-7/abstract
The global burden of antimicrobial resistance – urinary tract infections

Sibylle Von Vietinghoff, Olga Shevchuk, Ulrich Dobrindt, Daniel Robert Engel, Selina K Jorch, Christian Kurts, Thomas Miethke, Florian Wagenlehner

2023 Oct 27

https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt/gfad233/7331453
Proteomic adaptations in the kidney reveal orchestration of local and secreted antimicrobial peptides in human pyelonephritis

Lars Borgards, Bente Siebels, Hannah Voss, Christoph Krisp, Jessica Schmitz, Lisa Schwarz, Devon Siemes, Philippa Spangenberg, Jan H. Bräsen, Sibylle von Vietinghoff, Hartmut Schlüter, Florian Wagenlehner, Daniel R. Engel, Olga Shevchuk

2023 Sep 17

https://www.biorxiv.org/content/10.1101/2023.09.14.557715v1
Mucosal-associated invariant T cells suppress inflammatory myeloid cell responses in immune-mediated kidney disease.

Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T. Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C*, Turner JE*

2023 Jun 07

https://pubmed.ncbi.nlm.nih.gov/37968302/
Fate mapping reveals compartment-specific clonal expansion of mononuclear phagocytes during kidney disease.

Yin J, Mei Q, Prinz M, Abdullah Z, Panzer U, Li J, von Vietinghoff S, Kurts C.

2023 Jun 06

https://www.kidney-international.org/article/S0085-2538(23)00401-5/fulltext
Auswahl laufender Forschungsprojekte

Adrian Goldspink, Jessica Schmitz, Olena Babyak, Nicolas Brauns, Julia Milleck, Anne M Breloh, Susanne V Fleig, Katarzyna Jobin, Lisa Schwarz, Hermann Haller, Florian Wagenlehner, Jan Hinrich Bräsen, Christian Kurts, Sibylle von Vietinghoff

2023 Apr 23

https://pubmed.ncbi.nlm.nih.gov/37098380/

DFG fördert sieben neue Forschungsgruppen, eine neue Klinische Forschungsgruppe und eine neue Kolleg-Forschungsgruppe

Deutsche Forschungsgemeinschaft

https://www.dfg.de/service/presse/pressemitteilungen/2022/pressemitteilung_nr_51/index.html

Auswahl laufender Forschungsprojekte

WWU Münster

https://www.medizin.uni-muenster.de/hygiene/forschung/forschungsprojekte.html